According to the GLOBOCAN reports, there were about 12.7 million cancer cases and 7.6
million cancer deaths in 2008, and the cancer burden continues to increase worldwide [1]. At …

The characterization of tumorassociated antigens recognized by human T lymphocytes in a
major histocompatibility complex (MHC) restricted fashion has opened new possibilities for …

Dendritic cells (DCs) were initially described in 1973 by Ralph Steinman, who observed in
mouse spleen a subpopulation of cells with a striking dendritic morphology. DCs originate …

The immunogenicity of tumors has been established. Aspecific stimulation of immunity, such
as by cytokine therapy, has been shown to induce durable clinical remissions in metastatic …

Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the
initiation of immune response. Based on the finding that the immune system usually fails to …

Antigen presentation is a critical regulatory element for the induction of cellular immune
responses. Thus, one of the principal current goals of tumor immunotherapy is to control and …

Dendritic cell (DC) vaccination in cancer patients aims to induce or augment an effective
antitumor immune response against tumor antigens and was first explored in a clinical trial …

ABSTRACT B and T lymphocytes are the effectors of specific immunity. However, their
function is critically dependent on dendritic cells (DC). DC are professional antigen …

Dendritic cells (DC) are recognized as the most potent antigen-presenting cells with the
ability to stimulate naive resting T cells and to initiate primary immune responses …

The discovery that dendritic cells (DC) play a key role in regulating antitumor immunity has
prompted considerable efforts in developing DC-based cancer vaccines for use in clinical …