Controlled delivery of chemotherapeutic agents by biodegradable polymers is a new
strategy that has been added to the arsenal available for the treatment of malignant …

Glioblastoma multiforme (GBM) has few clinically approved therapeutic regimens. One of
these therapeutic options includes placing biodegradable wafers releasing BCNU …

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumour in
adults with a very poor prognosis. This paper describes the development of disulfiram (DSF) …

Systemic administration of anticancer therapeutic agents remains a crucial strategy for
clinical cancer therapy. However, poor drug accumulation at tumor sites and severe side …

Glioblastoma multiforme (GBM) is a highly advanced and invasive brain tumor due to which
current treatments cannot completely treat GBM or prevent recurrence. Therefore, adjunctive …

In spite of remarkable improvements in cancer treatments and survivorship, cancer still
remains as one of the major causes of death worldwide. Although current standards of care …

When hydrogel materials with excellent biocompatibility and biodegradability are used as
excellent new drug carriers in the treatment of cancer, they confer the following three …

Purpose The brain, protected by the cranium externally and the blood–brain barrier (BBB)
internally, poses challenges in chemotherapy of aggressive brain tumors. Maximal tumor …

Background: Despite significant advances in neurosurgery, radiation therapy, and
chemotherapy, the prognosis for patients with malignant brain tumors remains dismal. In an …

Background Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy
(RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) …