Targeting immune cell recruitment in atherosclerosis

Y Döring, EPC van der Vorst, C Weber - Nature Reviews Cardiology, 2024 - nature.com
Atherosclerosis is the primary underlying cause of myocardial infarction and stroke.
Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory reaction …

Inflammatory cell recruitment in cardiovascular disease

T Marchini, LS Mitre, D Wolf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Atherosclerosis, the main underlying pathology for myocardial infarction and stroke, is a
chronic inflammatory disease of middle-sized to large arteries that is initiated and …

Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis

B Zarzycka, GAF Nicolaes, E Lutgens - Expert review of clinical …, 2015 - Taylor & Francis
Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. Current
treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or …

Immune and smooth muscle cells interactions in atherosclerosis: how to target a breaking bad dialogue?

D Ramel, S Gayral, MK Sarthou, N Augé… - Frontiers in …, 2019 - frontiersin.org
Inflammation is a well-known pathophysiological factor of atherosclerosis but its therapeutic
targeting has long been ignored. However, recent advances in the understanding of the …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Vascular inflammation in cardiovascular disease: Is immune system protective or bystander?

K Muhammad, MA Ayoub… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Chronic
atherosclerosis induced vascular inflammation and perturbation of lipid metabolism is …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges

T Kyaw, K Peter, Y Li, P Tipping… - British Journal of …, 2017 - Wiley Online Library
Cytotoxic lymphocytes encompass natural killer lymphocytes (cells) and cytotoxic T cells that
include CD8+ T cells, natural killer (NK) T cells, γ, δ (γδ)‐T cells and human CD4+ CD28− T …

Atherosclerosis: cell biology and lipoproteins–focus on anti-inflammatory therapies

S Pfeiler, N Gerdes - Current Opinion in Lipidology, 2018 - journals.lww.com
Cardiovascular disease (CVD) continues to pose the worldwide leading cause of death in
the general population. Atherosclerosis, the underlying disease of a majority of strokes and …

Immune and autoimmune mechanisms in cardiovascular disease

H Winkels, N Gerdes, F Kahles, P Dutta… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis and its sequelae, myocardial infarction, ischemic heart disease, and stroke
remain the leading cause of mortality worldwide. A large body of clinical and pre-clinical …