K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders

JD Leavenworth, N Yusuf… - Critical Reviews™ in …, 2024 - dl.begellhouse.com
ABSTRACT K homology-type splicing regulatory protein (KSRP) is emerging as a key player
in cancer biology, and immunology. As a single-strand nucleic acid binding protein it …

The role of KH-type splicing regulatory protein (KSRP) for immune functions and tumorigenesis

KA Palzer, V Bolduan, R Käfer, H Kleinert, M Bros… - Cells, 2022 - mdpi.com
Post-transcriptional control of gene expression is one important mechanism that enables
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …

[PDF][PDF] The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis. Cells 2022, 11, 1482

KA Palzer, V Bolduan, R Käfer, H Kleinert, M Bros… - 2022 - openscience.ub.uni-mainz.de
Post-transcriptional control of gene expression is one important mechanism that enables
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …

Role of KSRP in control of type I interferon and cytokine expression

PH King, CY Chen - Journal of Interferon & Cytokine Research, 2014 - liebertpub.com
Cytokines and chemokines are key participants in pathways that drive inflammatory,
immune, and other cellular responses to exogenous insults such as infection, trauma, and …

Splicing regulators and their roles in cancer biology and therapy

MR da Silva, GA Moreira… - BioMed research …, 2015 - Wiley Online Library
Alternative splicing allows cells to expand the encoding potential of their genomes. In this
elegant mechanism, a single gene can yield protein isoforms with even antagonistic …

Diverse roles of the nucleic acid‐binding protein KHSRP in cell differentiation and disease

P Briata, D Bordo, M Puppo, F Gorlero… - Wiley …, 2016 - Wiley Online Library
The single‐stranded nucleic acid‐binding protein KHSRP (KH‐type splicing regulatory
protein) modulates RNA life and gene expression at various levels. KHSRP controls …

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

HY Wang, W Lin, JA Dyck, JM Yeakley… - The Journal of cell …, 1998 - rupress.org
Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian
cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to …

KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer

MH Chien, WJ Lee, YC Yang, YL Li, BR Chen… - … et Biophysica Acta (BBA …, 2017 - Elsevier
KH-type splicing regulatory protein (KSRP) is a single-strand RNA binding protein which
regulates mRNA stability either by binding to AU-rich elements (AREs) of mRNA 3′ UTR or …

The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets

MF García-Mayoral, I Díaz-Moreno… - Nucleic acids …, 2008 - academic.oup.com
K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein
that regulates different steps of mRNA metabolism, from mRNA splicing to mRNA decay …

The tumor-permissive role of KHSRP in colorectal cancer: Mechanistic insights from a gene expression study

F Caiazza, R Power, K Killick, D Higgins, W Kolch… - Cancer Research, 2016 - AACR
Inflammation plays a key role in the development of Colorectal Cancer (CRC), but the
underlying regulatory mechanisms are yet to be fully elucidated. The K-homology splicing …