K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders
JD Leavenworth, N Yusuf… - Critical Reviews™ in …, 2024 - dl.begellhouse.com
ABSTRACT K homology-type splicing regulatory protein (KSRP) is emerging as a key player
in cancer biology, and immunology. As a single-strand nucleic acid binding protein it …
in cancer biology, and immunology. As a single-strand nucleic acid binding protein it …
The role of KH-type splicing regulatory protein (KSRP) for immune functions and tumorigenesis
KA Palzer, V Bolduan, R Käfer, H Kleinert, M Bros… - Cells, 2022 - mdpi.com
Post-transcriptional control of gene expression is one important mechanism that enables
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …
[PDF][PDF] The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis. Cells 2022, 11, 1482
KA Palzer, V Bolduan, R Käfer, H Kleinert, M Bros… - 2022 - openscience.ub.uni-mainz.de
Post-transcriptional control of gene expression is one important mechanism that enables
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …
stringent and rapid modulation of cytokine, chemokines or growth factors expression, all …
Role of KSRP in control of type I interferon and cytokine expression
PH King, CY Chen - Journal of Interferon & Cytokine Research, 2014 - liebertpub.com
Cytokines and chemokines are key participants in pathways that drive inflammatory,
immune, and other cellular responses to exogenous insults such as infection, trauma, and …
immune, and other cellular responses to exogenous insults such as infection, trauma, and …
Splicing regulators and their roles in cancer biology and therapy
MR da Silva, GA Moreira… - BioMed research …, 2015 - Wiley Online Library
Alternative splicing allows cells to expand the encoding potential of their genomes. In this
elegant mechanism, a single gene can yield protein isoforms with even antagonistic …
elegant mechanism, a single gene can yield protein isoforms with even antagonistic …
Diverse roles of the nucleic acid‐binding protein KHSRP in cell differentiation and disease
The single‐stranded nucleic acid‐binding protein KHSRP (KH‐type splicing regulatory
protein) modulates RNA life and gene expression at various levels. KHSRP controls …
protein) modulates RNA life and gene expression at various levels. KHSRP controls …
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells
HY Wang, W Lin, JA Dyck, JM Yeakley… - The Journal of cell …, 1998 - rupress.org
Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian
cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to …
cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to …
KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer
MH Chien, WJ Lee, YC Yang, YL Li, BR Chen… - … et Biophysica Acta (BBA …, 2017 - Elsevier
KH-type splicing regulatory protein (KSRP) is a single-strand RNA binding protein which
regulates mRNA stability either by binding to AU-rich elements (AREs) of mRNA 3′ UTR or …
regulates mRNA stability either by binding to AU-rich elements (AREs) of mRNA 3′ UTR or …
The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets
MF García-Mayoral, I Díaz-Moreno… - Nucleic acids …, 2008 - academic.oup.com
K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein
that regulates different steps of mRNA metabolism, from mRNA splicing to mRNA decay …
that regulates different steps of mRNA metabolism, from mRNA splicing to mRNA decay …
The tumor-permissive role of KHSRP in colorectal cancer: Mechanistic insights from a gene expression study
Inflammation plays a key role in the development of Colorectal Cancer (CRC), but the
underlying regulatory mechanisms are yet to be fully elucidated. The K-homology splicing …
underlying regulatory mechanisms are yet to be fully elucidated. The K-homology splicing …