Gap junctional intercellular communication (GJIC) is considered to play a key role in the
maintenance of tissue independence and homeostasis in multicellular organisms by …

Malignant cells usually show altered gap junctional intercellular communication and are
often associated with aberrant expression or localization of connexins. Transfection of …

In order to examine whether different connexin gene species exert different degrees of tumor-
suppressing activity, we characterized growth characteristics of a gap junction-deficient …

Connexin genes exert negative growth control when transfected into various types of tumor
cell lines. We previously demonstrated that connexin 26 (Cx26) suppresses in vitro and in …

The hypothesis, that gap junctional intercellular communication plays a key role in
carcinogenesis and more generally in growth control was formulated nearly 40 years ago …

Our laboratory has previously reported that transfection of a connexin26 (Cx26) gene, but
not connexin40 nor connexin43 (Cx43), into HeLa cells expressing no detectable level of …

Gap junctions are cellular structures which permit direct exchanges of small molecules from
cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has …

During multistage carcinogenesis, multiple genetic changes progressively accumulate in a
cell until it acquires a complete set of altered genes necessary for malignant phenotype …

Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—
connexins—often occurs in, and sometimes causes, a variety of proliferative disorders …

Many lines of evidence support the hypothesis that connexins form a family of tumor‐
suppressor genes. Transfection of connexin43 (Cx43) into rat C6 glioma cells have revealed …