Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Taste receptors on the tongue communicate information to the brain about the nutrient
content or potential toxicity of ingested foods. However, recent research has now shown that …

Bitter (T2R) and sweet (T1R) taste receptors have been implicated in sinonasal innate
immunity and in the pathophysiology of chronic rhinosinusitis (CRS). Taste receptors are …

The bitter taste receptor T2R38 has been shown to play a role in the pathogenesis of chronic
rhinosinusitis (CRS), where the receptor functions to enhance upper respiratory innate …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …

Bitter taste receptors (T2Rs) localize to airway motile cilia and initiate innate immune
responses in retaliation to bacterial quorum sensing molecules. Activation of cilia T2Rs …

Taste receptors are well known for their role in communicating information from the tongue
to the brain about nutritional value or potential toxicity of ingested substances. More recently …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …