Rationale: Intratidal changes in regional lung aeration, as assessed with dynamic four-
dimensional computed tomography (CT; 4DCT), may indicate the processes of recruitment …

We used dynamic CT to identify two different time constants of lung aeration and their
individual contribution to the total increase in cross‐sectional lung area in healthy and …

Introduction Spatial heterogeneity of lung aeration and strain (change volume/resting
volume) occurs at microscopic levels and contributes to lung injury. Yet, it is mostly assessed …

Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Computed tomography (CT) can yield quantitative information about volume distribution in
the lung. By combining information provided by CT and respiratory mechanics, this study …

Background Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal,
physiological variation in aeration and lung density in experimental lung injury. The ability of …

Background: Computed tomography is the gold standard for lung aeration assessment, but
exposure to ionizing radiation limits its application. We assessed the ability of magnetic …

Heterogeneity in regional end expiratory lung volume (EELV) may lead to variations in
regional strain (ε). High ε levels have been associated with ventilator‐associated lung injury …

Abstract Image Functional Modeling (IFM) synthesizes three dimensional airway networks
with imaging and mechanics data to relate structure to function. The goal of this study was to …

Increased dead space is an important prognostic marker in early acute respiratory distress
syndrome (ARDS) that correlates with mortality. The cause of increased dead space in …