Nucleophosmin (NPM1) mutation is one of the most common recurring genetic
abnormalities seen in acute myeloid leukemia (AML). Immunohistochemistry serves as a …

BACKGROUND AND OBJECTIVES: Acute myeloid leukemia (AML) with mutated
nucleophosmin (NPM) gene has distinctive clinical and molecular features, and enormous …

Methods: NPM protein IHC was performed using mouse anti-NPM monoclonal antibody on
35 paraffin-embedded bone marrow biopsies of patients with primary AML of any French …

Abstract BACKGROUND: Nucleophosmin (NPM1) gene mutations are reported to predict a
favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic …

Abstract Introduction. Nucleophosmin (NPM1) gene mutations occur in 50-60% of adult AML
with normal karyotype (Falini et al, NEJM 2005). About 50 NPM1 mutations have been so far …

Mutations of the nucleophosmin (NPM-1) gene have been reported in 50–60% of acute
myeloid leukemia (AML) patients with normal karyotype. This work was designed to study …

OBJECTIVE: Somatic mutations of the nucleophosmin gene (NPM1), which alter the
subcellular localization of the product, are the most frequent mutations in patients with acute …

Nucleophosmin (NPM1) gene mutations resulting in cytoplasmic delocalization of
Nucleophosmin (NPMc+) are the most common genetic alteration in acute myeloid leukemia …

Abstract Introduction Nucleophosmin 1 (NPM1) mutation is one of the most frequent gene
mutations in adult acute myeloid leukemia (AML), being detected in 35% of all cases and in …

Objective/Background Nucleophosmin 1 (NPM1) plays multiple roles in cell growth and
proliferation. Deletion/insertion mutations in exon 12 of NPM1 (NPM1-DIM), commonly found …