[PDF][PDF] High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses

D Bermudez, F León-Velarde - researchgate.net
Increased production of red blood cells (RBCs), or erythrocytosis, has been considered a
hallmark response of acclimatization in lowlanders at high altitude since its first description …

High-altitude erythrocytosis: mechanisms of adaptive and maladaptive responses

FC Villafuerte, TS Simonson, D Bermudez… - …, 2022 - journals.physiology.org
Erythrocytosis, or increased production of red blood cells, is one of the most well-
documented physiological traits that varies within and among in high-altitude populations …

Molecular basis of hypoxia induced excessive erythrocytosis

P Azad, G Haddad - The FASEB Journal, 2017 - Wiley Online Library
Objective Since polycythemia is a predominant trait in some high altitude dwellers (Chronic
Mountain Sickness, CMS, or Monge's disease) but not others living at the same altitude in …

Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness

D Bermudez, P Azad… - American Journal …, 2020 - journals.physiology.org
Excessive erythrocytosis (EE) is the main sign of chronic mountain sickness (CMS), a
maladaptive clinical syndrome prevalent in Andean and other high-altitude populations …

Hematological parameters of high and low altitude Tibetan populations

N Basak, T Norboo, MS Mustak, K Thangaraj - bioRxiv, 2020 - biorxiv.org
High altitude hypoxia is believed to be experienced at elevations more than 2500 meters. A
few studies have shed light on the biochemical aspects of high altitude acclimatization that …

High altitude polycythemia and its maladaptive mechanisms: an updated review

S Tang, W Zhou, L Chen, H Yan, L Chen… - Frontiers in Medicine, 2024 - frontiersin.org
High altitude polycythemia is a maladaptation of highlanders exposed to hypoxic
environment, leading to high blood viscosity and severe cardiorespiratory dysfunction …

Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru

MS Painschab, GE Malpartida… - … altitude medicine & …, 2015 - liebertpub.com
Abstract Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H.
Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley …

Regulation of haemoglobin concentration at high altitude

C Siebenmann, J Roche, M Schlittler… - The Journal of …, 2023 - Wiley Online Library
Lowlanders sojourning for more than 1 day at high altitude (HA) experience a reduction in
plasma volume (PV) that increases haemoglobin concentration and thus restores arterial …

Enhanced erythropoietin production during hypobaric hypoxia in mice under treatments to keep the erythrocyte mass from rising: implications for the adaptive role of …

CE Bozzini, AC Barceló, MI Conti… - … Altitude Medicine & …, 2005 - liebertpub.com
Bozzini, Carlos E., Ana C. Barceló, María I. Conti, María P. Martínez, and Rosa M. Alippi.
Enhanced erythropoietin production during hypobaric hypoxia in mice under treatments to …

Molecular basis of hypoxia‐induced excessive erythrocytosis of high altitude

P Azad, G Haddad - The FASEB Journal, 2018 - Wiley Online Library
Rationale Since polycythemia is a predominant trait in some high altitude dwellers (Chronic
Mountain Sickness, CMS, or Monge's disease) but not others living at the same altitude in …