Traumatic brain injury (TBI) has been a crucial health problem, with more than 50 million
patients worldwide each year. Glymphatic system is a fluid exchange system that relies on …

Background: It is reported that the expression of aquaporin4 (AQP4) in the brain is increased
and leads to the brain edema after subarachnoid hemorrhage (SAH). In this study, by using …

The water channel aquaporin-4 (AQP4) is important in brain water homeostasis, and is also
involved in astrocyte growth and glial scar formation. It has been reported that AQP4 …

Aquaporin-4 (AQP4) plays an important role in regulating water exchange across the blood-
brain barrier (BBB) and brain-cerebrospinal fluid interface. Studies on AQP-4 knockout mice …

Background Traumatic brain edema (TBE) is caused by a specific water channel mediated
by membrane aquaporins. Aquaporin-4 (AQP4) plays an especially important role in this …

Abstract Aquaporin 4 (AQP4) is a widely distributed membrane protein, which is found in
glial cells, ependymocytes and capillary endothelial cells in the brain, and particularly in the …

Micro traumatic brain injury (TBI) is the most common type of brain injury, but the
mechanisms underlying it are poorly understood. Aquaporin-4 (AQP4) is a water channel …

Abstract 'Secondary insult'following primary traumatic brain injury (TBI), including ischemia
and edema, may aggravate brain impairments and affect the outcomes. The hippocampus is …

The mechanism of brain injury following subarachnoid hemorrhage (SAH) has not yet been
clarified. The glymphatic system (GS), a glia-dependent waste clearance pathway, drains …

SUMMARY Background and Purpose: The glial water channel aquaporin‐4 (AQP4) has
been shown to be involved in a wide range of brain disorders. Although its important role in …