The Nature of the Fungal Cargo Induces Significantly Different Temporal Programmes of Macrophage Phagocytosis

NAR Gow, MF Alonso, JM Bain, FM Rudkin… - Available at SSRN … - papers.ssrn.com
Phagocytosis is an essential component of our immune defence against fungal pathogens.
Differences in the dynamics of phagocyte migration, recognition, uptake and …

[HTML][HTML] The nature of the fungal cargo induces significantly different temporal programmes of macrophage phagocytosis

MF Alonso, JM Bain, FM Rudkin, LP Erwig, AJP Brown… - The Cell Surface, 2022 - Elsevier
Phagocytosis is an essential component of our immune defence against fungal pathogens.
Differences in the dynamics of phagocyte migration, recognition, uptake and …

In fungal intracellular pathogenesis, form determines fate

RC May, A Casadevall - MBio, 2018 - Am Soc Microbiol
For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful
microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans …

[PDF][PDF] Fungal Biology

MF Alonso, JM Bain, LP Erwig, AJP Brown, NAR Gow - researchgate.net
Macrophages play critical protective roles as sentinels of the innate immune system against
fungal infection. It is therefore important to understand the dynamics of the interaction …

[HTML][HTML] Hyphal swelling induced in the phagosome of macrophages

MF Alonso, JM Bain, LP Erwig, AJP Brown, NAR Gow - Fungal Biology, 2024 - Elsevier
Macrophages play critical protective roles as sentinels of the innate immune system against
fungal infection. It is therefore important to understand the dynamics of the interaction …

Novel insights into host-fungal pathogen interactions derived from live-cell imaging

J Bain, NAR Gow, LP Erwig - Seminars in Immunopathology, 2015 - Springer
The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959
lecture,“There's plenty of room at the bottom”, the enormous possibility of producing and …

[HTML][HTML] Live-cell video microscopy of fungal pathogen phagocytosis

LE Lewis, JM Bain, B Okai, NAR Gow… - Journal of visualized …, 2013 - pmc.ncbi.nlm.nih.gov
Phagocytic clearance of fungal pathogens, and microorganisms more generally, may be
considered to consist of four distinct stages:(i) migration of phagocytes to the site where …

Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities

LJ Jia, K González, T Orasch, F Schmidt… - Nature …, 2024 - nature.com
An important host defence mechanism against pathogens is intracellular killing, which is
achieved through phagocytosis, a cellular process for engulfing and neutralizing …

Recognition of yeast by murine macrophages requires mannan but not glucan

S Keppler-Ross, L Douglas, JB Konopka… - Eukaryotic Cell, 2010 - Am Soc Microbiol
The first barrier against infection by Candida albicans involves fungal recognition and
destruction by phagocytic cells of the innate immune system. It is well established that …

Interactions of fungal pathogens with phagocytes

LP Erwig, NAR Gow - Nature Reviews Microbiology, 2016 - nature.com
The surveillance and elimination of fungal pathogens rely heavily on the sentinel behaviour
of phagocytic cells of the innate immune system, especially macrophages and neutrophils …