Vascular endothelial growth factor and angiogenesis

ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications

N Ferrara - Seminars in oncology, 2002 - Elsevier
Angiogenesis, or formation of new blood vessels from pre-existing ones, is essential for
normal development and wound healing/reproductive functions in adults. Abnormal …

Molecular and biological properties of vascular endothelial growth factor

N Ferrara - Journal of molecular medicine, 1999 - Springer
Vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and
abnormal angiogenesis. Recent evidence indicates that VEGF is essential for embryonic …

Vascular endothelial growth factor: much more than an angiogenesis factor

DR Senger - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Vascular endothelial growth factor (VEGF) is best known as a cytokine essential for
embryonic vasculogenesis and for the angiogenesis associated with various pathologies …

Angiogenesis—a new target for future therapy

NM Pandya, NS Dhalla, DD Santani - Vascular pharmacology, 2006 - Elsevier
Development of blood vessels from in situ differentiating endothelial cells (EC) is called
vasculogenesis, whereas sprouting of new blood vessels from the pre-existing ones is …

Basic science review: current insights on the biology and clinical aspects of VEGF regulation

DM Birk, J Barbato, L Mureebe… - Vascular and …, 2009 - journals.sagepub.com
Vascular endothelial growth factor (VEGF) is a key molecule that orchestrates the formation
and function of vascular networks. Impaired regulation of angiogenesis is implicated in a …

Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia

TD Crafts, AR Jensen, EC Blocher-Smith, TA Markel - Cytokine, 2015 - Elsevier
Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in
angiogenesis and vasculogenesis. The contemporary body of literature contains a …

Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)

AM Byrne, DJ Bouchier‐Hayes… - Journal of cellular and …, 2005 - Wiley Online Library
Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell
specific growth factor stimulating angiogenesis and vascular permeability. Some family …

VEGF in biological control

EC Breen - Journal of cellular biochemistry, 2007 - Wiley Online Library
Vascular endothelial growth factor A (VEGF‐A) belongs to a family of heparin binding growth
factors that include VEGF‐B, VEGF‐C, VEGF‐D, and placental‐like growth factor (PLGF) …

VEGF function in vascular pathogenesis

YS Ng, D Krilleke, DT Shima - Experimental cell research, 2006 - Elsevier
Vascular endothelial growth factor (VEGF) has proven to be the most critical angiogenic
factor identified to date; its discovery has transformed the field of angiogenesis research …