Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …

Ocular irritation and pain are associated with many clinical situations (eg accidental injury,
eye diseases, surgery and contact lens wearing). Pain and related ocular sensations begin …

The altered activity generated by corneal neuronal injury can result in morphological and
physiological changes in the architecture of synaptic connections in the nervous system …

The cornea is a valuable tissue for studying peripheral sensory nerve structure and
regeneration due to its avascularity, transparency, and dense innervation. Somatosensory …

Corneal pain is mediated by primary afferent fibers projecting to the dorsal horn of the
medulla, specifically the trigeminal nucleus caudalis. In contrast to reflex responses, the …

Ocular surface diseases are among the most frequent ocular pathologies, with prevalence
ranging from 20% of the general population. In addition, ocular pain following corneal injury …

While physiological pain (nociceptive pain) has a protective role in warning of potential
tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic …

Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

Dorsal horn neurons send ascending projections to both thalamic nuclei and parabrachial
nuclei; these pathways are thought to be critical pathways for central processing of …

Dry eye disease (DED) is a multifactorial disease characterized by a loss of homeostasis of
the tear film and accompanied by ocular symptoms, in which tear film instability and …