Selection on plastic adherence leads to hyper-multicellular strains and incidental virulence in the budding yeast

LI Ekdahl, JA Salcedo, MM Dungan, DV Mason… - Elife, 2023 - elifesciences.org
Many disease-causing microbes are not obligate pathogens; rather, they are environmental
microbes taking advantage of an ecological opportunity. The existence of microbes whose …

[HTML][HTML] Exploring accidental virulence

DFQ Smith - Elife, 2024 - elifesciences.org
Pathogen Evolution: Exploring accidental virulence | eLife Skip to Content eLife logo eLife
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General factors important for the formation of structured biofilm-like yeast colonies

V Št'ovíček, L Váchová, M Kuthan, Z Palková - Fungal Genetics and …, 2010 - Elsevier
The lifestyle of wild and laboratory yeast strains significantly differs. In contrast to the smooth
colonies of laboratory strains, wild Saccharomyces cerevisiae strains form biofilm-like …

Biofilm formation and toxin production provide a fitness advantage in mixed colonies of environmental yeast isolates

BM Deschaine, AR Heysel, BA Lenhart… - Ecology and …, 2018 - Wiley Online Library
Microbes can engage in social interactions ranging from cooperation to warfare. Biofilms are
structured, cooperative microbial communities. Like all cooperative communities, they are …

Investigating filamentous growth and biofilm/mat formation in budding yeast

PJ Cullen - Cold Spring Harbor Protocols, 2015 - cshprotocols.cshlp.org
In response to nutrient limitation, budding yeast can undergo filamentous growth by
differentiating into elongated chains of interconnected cells. Filamentous growth is regulated …

[HTML][HTML] Global changes in gene expression associated with phenotypic switching of wild yeast

V Šťovíček, L Váchová, M Begany, D Wilkinson… - Bmc Genomics, 2014 - Springer
Background Saccharomyces cerevisiae strains isolated from natural settings form structured
biofilm colonies that are equipped with intricate protective mechanisms. These wild strains …

Ploidy-Regulated Variation in Biofilm-Related Phenotypes in Natural Isolates of Saccharomyces cerevisiae

EA Hope, MJ Dunham - G3: Genes, Genomes, Genetics, 2014 - academic.oup.com
The ability of yeast to form biofilms contributes to better survival under stressful conditions.
We see the impact of yeast biofilms and “flocs”(clumps) in human health and industry, where …

Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast

Z Farkas, K Kovács, Z Sarkadi, D Kalapis… - Nature Ecology & …, 2022 - nature.com
Deleterious mutations are generally considered to be irrelevant for morphological evolution.
However, they could be compensated by conditionally beneficial mutations, thereby …

Genetic Basis for Saccharomyces cerevisiae Biofilm in Liquid Medium

KS Andersen, R Bojsen, LGR Sørensen… - G3: Genes …, 2014 - academic.oup.com
Biofilm-forming microorganisms switch between two forms: free-living planktonic and sessile
multicellular. Sessile communities of yeast biofilms in liquid medium provide a primitive …

Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity

HB Fraser, S Levy, A Chavan, HB Shah… - Genome …, 2012 - genome.cshlp.org
The acquisition of new genes, via horizontal transfer or gene duplication/diversification, has
been the dominant mechanism thus far implicated in the evolution of microbial …