Aim Abiraterone acetate for metastatic castration-resistant prostate cancer is an acetylated
prodrug to be hydrolyzed to abiraterone. Abiraterone acetate is known to be hydrolyzed by …

Human arylacetamide deacetylase (AADAC) hydrolyzes various drugs containing an acetyl
group, such as ketoconazole and rifampicin. Knowledge about the role of human AADAC in …

Introduction: Androgen signaling axis (ASA) continues to play a crucial role in castration-
resistant prostate cancer (CRPC). One of the proposed mechanisms is the activation of ASA …

Arylacetamide deacetylase (AADAC) is involved in drug hydrolysis and lipid metabolism. In
23 human liver samples, no significant correlation was observed between AADAC mRNA …

In April 2011, abiraterone acetate (AA) was approved by the US Food and Drug
Administration (FDA) for the treatment of metastatic castration‐resistant prostate cancer …

Recently, in addition to carboxylesterases (CESs), we found that arylacetamide deacetylase
(AADAC) plays an important role in the metabolism of some clinical drugs. In this study, we …

Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of
castration-resistant prostate cancer. Abiraterone is metabolized in patients to a more potent …

Objective To describe the incidence and clinical relevance of biochemical and objective
responses to abiraterone acetate (AA) withdrawal (AAWD) in patients with castration …

A sensitive and selective LC–MS/MS method has been developed and validated for the
quantification of abiraterone acetate and its metabolite, abiraterone (an androgen …

Prasugrel, a thienopyridine anti-platelet agent, is pharmacologically activated by hydrolysis
and hydroxylation. It is efficiently hydrolyzed in the intestine after oral administration, and the …