In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a
chronic disease correlated with systemic inflammation, characterized by the presence of …

Background: Chronic low-grade inflammation and activation of the immune system are
hallmark pathogenic mechanisms involved in metabolic dysfunction and are related to …

Metabolic homoeostasis in adipose tissue plays a major role in obesity-related insulin
resistance (IR). Regulatory T (Treg) cells have been recorded to regulate metabolic …

Type 1 diabetes (T1D) is autoimmune destruction of the beta cells of pancreatic islets. Due
to complexity of that disease, the mechanisms leading to the tolerance breakdown are still …

Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM)
encompasses inflammation and autoimmune aspects is increasingly recognized. In the state …

Background Obesity has been a growing problem in young patients leading to serious
metabolic complications. There are many studies supporting the idea, that obesity should be …

Background Chronic low-grade inflammation and dysfunction of metabolism has been
reported to be involved in obesity. Regulatory T cell (Treg) and helper T cell 17 (Th17) are …

Background: Recent data suggest that an increased prevalence of interferon-gamma (IFN-γ)
producing CD4+ cells is present in obesity. Regulatory T cells (Tregs) have a strong impact …

Adipose tissue inflammation in obese patients can cause a series of metabolic diseases.
There are a variety of immune cells in adipose tissue, and studies have shown that T cells …

Obesity-related chronic low-grade inflammation may trigger insulin resistance and type 2
diabetes (T2D) development. Cells with regulatory phenotype have been shown to be …