Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

JL Stoudenmire, AN Greenawalt… - Frontiers in Cellular and …, 2022 - frontiersin.org
Transition metals are essential for metalloprotein function among all domains of life.
Humans utilize nutritional immunity to limit bacterial infections, employing metalloproteins …

Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity

IK Liyayi, AL Forehand, JC Ray, AK Criss - PLoS Pathogens, 2023 - journals.plos.org
The bacterium Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhea.
N. gonorrhoeae is an obligate human pathogen that colonizes mucosal surfaces of the …

Transition metals at the host–pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc

W Neumann, RC Hadley, EM Nolan - Essays in biochemistry, 2017 - portlandpress.com
Transition metals are essential nutrients for all organisms and important players in the host–
microbe interaction. During bacterial infection, a tug-of-war between the host and microbe …

Neisseria gonorrhoeae Modulates Iron-Limiting Innate Immune Defenses in Macrophages

SM Zughaier, JL Kandler, WM Shafer - PloS one, 2014 - journals.plos.org
Neisseria gonorrhoeae is a strict human pathogen that causes the sexually transmitted
infection termed gonorrhea. The gonococcus can survive extracellularly and intracellularly …

Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae

AH Branch, JL Stoudenmire, KL Seib… - Frontiers in Cellular …, 2022 - frontiersin.org
Neisseria gonorrhoeae and Neisseria meningitidis are human-specific pathogens in the
Neisseriaceae family that can cause devastating diseases. Although both species inhabit …

Metal-limited growth of Neisseria gonorrhoeae for characterization of metal-responsive genes and metal acquisition from host ligands

S Maurakis, CN Cornelissen - JoVE (Journal of Visualized Experiments), 2020 - jove.com
Trace metals such as iron and zinc are vital nutrients known to play key roles in prokaryotic
processes including gene regulation, catalysis, and protein structure. Metal sequestration by …

Characterization of the effects of iron on Neisseria gonorrhoeae surface protein modulation and host cell interactions

A Oki - 2014 - scholarscompass.vcu.edu
Iron is an essential nutrient that is sequestered by iron-binding proteins in the human host
resulting in a hostile environment for microbes. Neisseria gonorrhoeae, however, can utilize …

Mechanisms of iron acquisition employed by Neisseria gonorrhoeae for survival within cervical epithelial cells

TA Hagen - 2006 - scholarscompass.vcu.edu
Neisseria gonowhoeae has evolved a repertoire of high-affinity iron acquisition systems to
facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy …

Neisseria gonorrhoeae requires expression of TonB and the putative transporter TdfF to replicate within cervical epithelial cells

TA Hagen, CN Cornelissen - Molecular microbiology, 2006 - Wiley Online Library
Neisseria gonorrhoeae has evolved a repertoire of iron acquisition systems that facilitate
essential iron uptake in the human host. Acquisition of iron requires both the energy …

Mutagenesis of the Loop 3 α-Helix of Neisseria gonorrhoeae TdfJ Inhibits S100A7 Binding and Utilization

SA Maurakis, JL Stoudenmire, JK Rymer, WJ Chazin… - Mbio, 2022 - Am Soc Microbiol
Neisseria gonorrhoeae causes the sexually transmitted infection (STI) gonorrhea, which
afflicts over 80 million people each year. No vaccine is available to prevent gonorrhea. The …