Overproduction of mucus and impaired clearance play important roles in the pathogenesis
of muco-obstructive lung diseases (MOLDs). This study aims to evaluate the therapeutic …

Objective Limited data exist concerning the role of inhaled hypertonic saline (HS) in
decreasing pulmonary exacerbations in cystic fibrosis (CF), especially as more advanced …

Background Hypertonic saline enhances mucociliary clearance and may lessen the
destructive inflammatory process in the airways. This is an update of a previously published …

Background Inhaled hypertonic saline (HS) is an effective mucolytic agent in patients with
cystic fibrosis (CF). However, adverse events can impair the clinical utility of hypertonic …

Bronchiectasis occurs as a result of a vicious circle consisting of an impaired mucociliary
transport system, inflammation, and infection and repair of the airways. Damage to the …

Background Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-
term trials, improves lung function in people with cystic fibrosis. We tested the safety and …

BACKGROUND AND AIMS: Inhalation of hypertonic saline (HTS) has short term positive
effects on airways clearance in non-cystic fibrosis (CF) bronchiectasis, however its long term …

Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The
major cause of mortality and morbidity is lung disease with increasing pulmonary …

Background In people with cystic fibrosis (CF), regular nebulisation of 6% or 7% saline
improves lung function; however, these concentrations are not always tolerable. Clinically …

Background: Hypertonic saline inhalation has been shown to be effective in patients with
cystic fibrosis and lung disease. However, adverse events including marked airway …