Background: Imipenem is a broad-spectrum β-lactam antibiotic frequently used for infectious
complications in ICU patients. Dosing optimisation still remains challenging for clinicians …

Background Imipenem is a broad-spectrum β-lactam antibiotic frequently used for infectious
complications in ICU patients. Dosing optimisation still remains challenging for clinicians …

Objective The objective of this study was to explore factors that affect the clearance of
imipenem in critically ill patients and to provide a dosing regimen for such patients. Methods …

Background Extracorporeal membrane oxygenation (ECMO), a cardiopulmonary bypass
device, has been found to increase the profound pathophysiological changes associated …

Population pharmacokinetic modeling and simulation (M&S) are used to improve antibiotic
dosing. Little is known about the differences in parametric and nonparametric M&S. Our …

Purpose The purpose of this study was to characterize the population-based
pharmacokinetic (POP-PK) profile of imipenem in Vietnamese adult patients and to assess …

Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients
because of the drastic variability of the patients' physiological parameters. Published …

Abstract Study Objectives The objectives of this study were (i) to determine the population
pharmacokinetic (PK) of imipenem in critically ill patients with life‐threatening severe …

Monte Carlo simulations allow prediction and comparison of concentration–time profiles
arising from different dosing regimens in a defined population, provided a population …

Background The appropriate dosing of imipenem for critically ill AKI patients undergoing
CRRT remains scarce. Purpose This study aimed to (1) gather the available published …