Germline editing, the process by which the genome of an individual is edited in such a way
that the change is heritable, has been applied to a wide variety of animals [DA Sorrell, AF …

Genetic modification of animals via selective breeding is the basis for modern agriculture.
The current breeding paradigm however has limitations, chief among them is the …

The first genetically modified large animals were generated in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs (1). Since then, it has been a …

The ability to directly manipulate the pig genome through genetic engineering has been
available to the research community for over three decades. This technology has …

Simple Summary Genetically modified farm animals have been actively used in a number of
applications from testing gene functions to increasing production and economic value of …

Historically, genetic engineering in livestock proved to be challenging. Without stable
embryonic stem cell lines to utilize, somatic cell nuclear transfer (SCNT) had to be employed …

The prospect of genome editing offers a number of promising opportunities for livestock
breeders. Firstly, these tools can be used in functional genomics to elucidate gene function …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Genetically modified animals, especially rodents, are widely used in biomedical research.
However, non-rodent models are required for efficient translational medicine and preclinical …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …