Genetic modification of livestock has a longstanding and successful history, starting with
domestication several thousand years ago. Modern animal breeding strategies …

Genetically-modified domestic animal models are of increasing significance in biomedical
research and agriculture. As authentic ES cells derived from domestic animals are not yet …

Genome editing in pigs has tremendous practical applications for biomedicine. The advent
of genome editing technology, with its use of site‐specific nucleases—including ZFNs …

The introduction of genome editing reagents into mammalian zygotes has traditionally been
accomplished by cytoplasmic or pronuclear microinjection. This time-consuming procedure …

Xenotransplantation, specifically the use of porcine organs for human transplantation, has
long been sought after as an alternative for patients suffering from organ failure. However …

16526–16531 (2013). 9. Medugorac, I. et al. Bovine polledness—an autosomal dominant
trait with allelic heterogeneity. PLoS ONE 7, e39477 (2012). 10. Olsen, PA, Gelazauskaite …

This issue of Animal Frontiers,“Farm animals are important biomedical models,” describes
several examples in which cattle, sheep, pigs, or chickens provide an excellent …

Transcription activator-like effector nuclease (TALEN) and zinc finger nuclease (ZFN)
genome editing technology enables site directed engineering of the genome. Here we …

Production of genome-edited animals using germline-competent cells and genetic
modification tools has provided opportunities for investigation of biological mechanisms in …

Since centuries, the traits for production and disease resistance are being targeted while
improving the genetic merit of domestic animals, using conventional breeding programs …