Introduction: Potential detrimental effects of hyperoxemia on outcomes have been reported
in critically ill patients. Little evidence exists on the effects of hyperoxygenation and …

Background In acute brain injury (ABI), the effects of hypoxemia as a potential cause of
secondary brain damage and poor outcome are well documented, whereas the impact of …

Patients with acute brain injury (ABI) often require the application of positive end-expiratory
pressure (PEEP) to optimize mechanical ventilation and systemic oxygenation. However, the …

Significant controversy exists regarding the potential clinical benefit of normobaric hyperoxia
(NBO) in patients with traumatic brain injury (TBI). This study consisted of two aims: 1) to …

Acute brain injury is associated with depressed aerobic metabolism. Below a critical
mitochondrial pO2 cytochrome c oxidase, the terminal electron acceptor in the mitochondrial …

Background Cerebral hypoxia is a frequent cause of secondary brain damage in patients
with acute brain injury. Although hypercapnia can increase intracranial pressure, it may …

Preliminary evidence suggests local brain tissue oxygenation (PbtO2) values of≤ 15 mm Hg
following severe traumatic brain injury (TBI) represent brain tissue hypoxia. Accordingly …

Background Normobaric oxygen therapy is frequently applied in neurocritical care, however,
whether supplemental FiO 2 has beneficial cerebral effects is still controversial. We …

Background: Ischemic and hypoxic secondary brain insults are common and detrimental in
traumatic brain injury (TBI). Treatment aims to maintain an adequate cerebral blood flow with …

Background Normobaric hyperoxia is used to alleviate secondary brain ischaemia in
patients with traumatic brain injury (TBI), but clinical evidence is limited and hyperoxia may …