Bone tissue is a continuous remodeling system, which is regulated by complex processes of
genetic and epigenetic control. Both the first and the second system in osteoporosis, as a …

Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Discovery of molecular mechanisms of primary osteoporosis development is fundamental to
understand the pathogenesis of musculoskeletal diseases in general and for identifying key …

Epigenetic modification pertains to the alteration of genetic-expression, which could be
transferred to the next generations, without any alteration in the fundamental DNA …

Fragile bone is the root cause of osteoporosis. For inherited or acquired reasons, the fragile
bone does not provide sufficient fracture resistance to withstand the physical strains of a …

This chapter will provide an up-to-date depiction of the molecular networks involved in the
osteogenic process, focusing on main genes and signaling pathways (schematically …

Epigenetics are such heritable modifications as DNA methylation, histone modification,
chromatin remodeling, as well as miRNA, without changes in DNA sequence. It has been …

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …