Novel insights into the complex architecture of osteoporosis molecular genetics

FA Saad - Annals of the New York Academy of Sciences, 2020 - Wiley Online Library
Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

Research progress of signaling pathways in osteoporosis

Y Zhang, Z Shen - Chinese Journal of Orthopaedics, 2017 - pesquisa.bvsalud.org
Osteoporosis is a systemic metabolic degenerative skeletal disease, characterized by
reduced bone mass and disrupted bone microarchitecture, leading to enhanced bone …

RETRACTED ARTICLE: Key genes associated with osteoporosis revealed by genome wide gene expression analysis

J Chen, L Wang, Y Shen, J Yu, T Ye, C Zhuang… - Molecular biology …, 2014 - Springer
Gene expression profiles of circulating monocytes were analyzed to identify key genes
associated with osteoporosis. Raw microarray data were downloaded from gene expression …

[PDF][PDF] The genetics of osteoporosis

GR Clark, EL Duncan - Br Med Bull, 2015 - Citeseer
Introduction: Osteoporosis is the commonest metabolic bone disease worldwide. The clinical
hallmark of osteoporosis is low trauma fracture, with the most devastating being hip fracture …

Osteoporosis: From osteoscience to neuroscience and beyond

P Kwan - Mechanisms of ageing and development, 2015 - Elsevier
Osteoporosis is well known to be a poly-factorial skeletal disorder characterized by a low
bone mineral density (BMD) at which the risk of developing fracture is remarkably increased …

Genetic control of bone mass

E Boudin, I Fijalkowski, G Hendrickx… - Molecular and cellular …, 2016 - Elsevier
Bone mineral density (BMD) is a quantitative traits used as a surrogate phenotype for the
diagnosis of osteoporosis, a common metabolic disorder characterized by increased fracture …

Epigenetic pathways regulating bone homeostasis

JB Lian - Bone, 2015 - Elsevier
Epigenetic control of the genome involves a complex series of unique, physiologically
responsive and integrated pathways, each with distinct mechanisms. Insight into epigenetic …

[引用][C] Molecular and genetic mechanisms of predisposition to osteoporosis

P Marozik, I Mosse, M Ameliyanovich, E Rudenka… - Gerontologija, 2011

[HTML][HTML] Molecular and cellular mechanisms of osteoporosis

IV Zhivodernikov, TV Kirichenko, YV Markina… - International journal of …, 2023 - mdpi.com
Osteoporosis is a widespread systemic disease characterized by a decrease in bone mass
and an imbalance of the microarchitecture of bone tissue. Experimental and clinical studies …

The molecular genetics of bone formation: implications for therapeutic interventions in bone disorders

PJ Marie - American Journal of Pharmacogenomics, 2001 - Springer
Skeletal biology is a complex process involving the developmental commitment and
differentiation of chondrocytes and osteoblasts which produce and mineralize cartilage and …