Reactive oxygen species (ROS) have been implicated in various types of CNS damage,
including stroke. We used a cultured astrocyte model to explore mechanisms of survival of …

Astrocytes can support neuronal survival through a range of secreted signals that protect
against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, analyzing the effects of …

Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous
System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1β …

The reticulon family has been found to induce apoptosis, inhibit axon regeneration and
regulate protein trafficking. However, little is known about the mechanisms of how reticulon …

Although the neuroprotective effects of Rac1 inhibition have been reported in various
cerebral ischemic models, the molecular mechanisms of action have not yet been fully …

The present study investigated whether there is an interaction between reactive oxygen
species (ROS) and p38 mitogen-activated protein kinase (MAPK) during chemical hypoxia …

Background Astrocytes exert a wide variety of functions in health and disease and respond
to a wide range of signaling pathways, including members of the Janus-kinase signal …

We earlier documented that lovastatin (LOV)‐mediated inhibition of small Rho GTPases
activity protects vulnerable oligodendrocytes (OLs) in mixed glial cell cultures stimulated …

Ischemic stroke causes lethal damage to the brain. Identifying key regulators of OGD/R-
induced cerebral injury is important for developing novel therapies for ischemic stroke …

Brain region specificity is a feature characteristic of neurodegenerative disorders, such as
Huntington's disease (HD). We have studied the brain region-specific vulnerability of striatal …