The heterotrimeric G proteins act as key molecular switches in eukaryotic cells to transmit
signals from hundreds of receptors to multiple effectors. The conventional theory of G protein …

Heterotrimeric G proteins are one of the most well studied signaling proteins. With hundreds
of different coupled receptors and multiple downstream effectors, G proteins constitute a …

Introduction. Activation of heterotrimeric G proteins is commonly believed to trigger the
dissociation of Gβγ dimers from GTP-bound Gα subunits. Such a model is mainly based on …

Heterotrimeric G proteins are composed of three subunits, α, β and γ. They are activated via
specific seven transmembrane receptors, G protein coupled receptor (GPCR), which …

G proteins transmit a variety of extracellular signals into intracellular responses. The Gα and
Gβγ subunits are both known to regulate effectors. Interestingly, the Gα subunit also …

The first 15 years, or so, brought the realization that there existed a G protein coupled signal
transduction mechanism by which hormone receptors regulate adenylyl cyclases and the …

Heterotrimeric G proteins regulate multiple effectors of which some are mediated via the Gβγ
dimers. There is evidence to suggest that the functions of Gβγ dimers are not shared by all …

Heterotrimeric G proteins relay information between cell surface receptors and effector
molecules in diverse signaling pathways to mediate critical cellular processes in both …

Historically, it has been assumed that the functional roles of G proteins in receptor
recognition and effector regulation are specified by their diverse α subunits. However, the …

Heterotrimeric G proteins (Gαβγ) are molecular switches that relay signals from 7-
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …