Background With apparent declines in malaria worldwide during the last decade and more
widespread use of malaria rapid diagnostic tests, healthcare workers in low-resource areas …

Background Increasing evidence is becoming available on the aetiology and management
of fevers in Asia; the importance of these fevers has increased with the decline in the …

Background The availability of reliable point-of-care tests for malaria has heralded a
paradigm shift in the management of febrile illnesses away from presumptive antimalarial …

Background African populations are considered to be particularly vulnerable to fever
illnesses, including malaria, and acute respiratory disease, owing to limited resources and …

Background The etiology and optimal clinical management of acute febrile illness (AFI) is
poorly understood. Methods Blood samples taken from study participants with acute fever …

Acute febrile illness (AFI) is one of the most common reasons for seeking medical care in
low-income and middle-income countries. Bacterial infections account for a relatively small …

Background Despite the fact that a large proportion of children with fever in Africa present at
primary health care facilities, few studies have been designed to specifically study the …

Objective Causes of acute febrile illness (AFI) often remain undetermined in developing
countries, due to overlap of symptoms and limited available diagnostics. We aimed to …

Objectives Areas with declining malaria transmission in sub-Saharan Africa have recently
witnessed important changes in the aetiology of childhood acute febrile illness (AFI). We …

A lack of simple, inexpensive, and rapid diagnostic tests for febrile illnesses other than
malaria leads to overtreatment with antibiotics for those who test negative for malaria, and …