Glioblastoma (GBM), the most common primary malignant brain tumor, is associated with a
dismal prognosis. Standard therapies including maximal surgical resection, radiotherapy …

Glioblastoma (GBM) is the most common malignant primary brain tumor, which despite
combined modality treatment, recurs and is invariably fatal. New therapies for GBM …

New, effective treatment strategies for glioblastomas (GBMs), the most malignant and
invasive brain tumors in adults, are highly needed. In this study, we investigated the …

Simple Summary Glioblastoma stem-like cells (GSCs) are responsible for most of the
malignant characteristics of glioblastoma, including therapeutic resistance, tumour …

Integrin-mediated signaling pathways have been found to promote the invasiveness and
survival of glioma cells by modifying the brain microenvironment to support the formation of …

Glioblastomas are malignant brain tumors with dismal prognosis despite standard treatment
with surgery and radio/chemotherapy. These tumors are defined by an important cellular …

Integrins are a large family of transmembrane adhesion receptors, which play a key role in
interactions of a cell with the surrounding stroma. Integrins are comprised of non-covalently …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

Integrins are a family of heterodimeric cell surface receptors that are expressed in most cells,
where they mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrin αvβ6 is …

Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired
resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of …