The integrin receptor αvβ3 has been shown to play a critical role in several distinct
processes, such as angiogenesis, osteoclast-mediated bone resorption and tumor …

Abstract αVβ3 integrin complexes are overexpressed in the growing, invading margins of
human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role …

Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer
cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche …

The integrin family of cell adhesion receptors is emerging as a promising target of anticancer
therapy. AlphaVbeta3 and alphaVbeta5 integrins are overexpressed on both glioma cells …

Integrins are a family of cell-extracellular matrix adhesion molecules that play important
roles in tumor angiogenesis. αvβ3-Integrin has received much attention as a potential anti …

OBJECTIVE: The biological features of malignant gliomas include high cell proliferation,
extensive local infiltration of tumor cells into normal brain, and marked neovascularization …

Transforming growth factor-β is a central mediator of the malignant phenotype of
glioblastoma, the most common and malignant form of intrinsic brain tumours. Transforming …

The integrin family of cell adhesion receptors has been studied extensively in cancer and is
implicated in tumor cell survival, migration, proliferation, and angiogenesis. 1 These …

Background: Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and
recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we …

Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …