Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer
M Zehner, M Alt, A Ashurov, JA Goldsmith, R Spies… - Immunity, 2023 - cell.com
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and
immunocompromised individuals. Currently, no vaccines are approved, and treatment …
immunocompromised individuals. Currently, no vaccines are approved, and treatment …
[HTML][HTML] Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus …
Human cytomegalovirus (HCMV) can cause life-threatening infection in immunosuppressed
patients, and in utero infection that may lead to birth defects. No vaccine is currently …
patients, and in utero infection that may lead to birth defects. No vaccine is currently …
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step
Human cytomegalovirus (HCMV) is one of the main causative agents of congenital viral
infection in neonates. HCMV infection also causes serious morbidity and mortality among …
infection in neonates. HCMV infection also causes serious morbidity and mortality among …
Potent bispecific neutralizing antibody targeting glycoprotein B and the gH/gL/pUL128/130/131 complex of human cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that can cause developmental
disorders following congenital infection and life-threatening complications among transplant …
disorders following congenital infection and life-threatening complications among transplant …
Neutralization of diverse human cytomegalovirus strains conferred by antibodies targeting viral gH/gL/pUL128-131 pentameric complex
S Ha, F Li, MC Troutman, DC Freed, A Tang… - Journal of …, 2017 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and
developing a prophylactic vaccine is of high priority to public health. We recently reported a …
developing a prophylactic vaccine is of high priority to public health. We recently reported a …
A novel strain-specific neutralizing epitope on glycoprotein H of Human Cytomegalovirus
M Thomas, B Kropff, A Schneider, TH Winkler… - Journal of …, 2021 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe clinical
disease in immunosuppressed patients and congenitally infected newborn infants. Viral …
disease in immunosuppressed patients and congenitally infected newborn infants. Viral …
Identification of a continuous neutralizing epitope within UL128 of human cytomegalovirus
F Chiuppesi, T Kaltcheva, Z Meng, PA Barry… - Journal of …, 2017 - Am Soc Microbiol
As human cytomegalovirus (HCMV) is the most common infectious cause of fetal anomalies
during pregnancy, development of a vaccine that prevents HCMV infection is considered a …
during pregnancy, development of a vaccine that prevents HCMV infection is considered a …
Structural basis for potent antibody-mediated neutralization of human cytomegalovirus
S Chandramouli, E Malito, TV Nguyen, K Luisi… - Science …, 2017 - science.org
Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and organ
transplant rejection. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the …
transplant rejection. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the …
A broadly neutralizing human monoclonal antibody generated from transgenic mice immunized with HCMV particles limits virus infection and proliferation
KE Atanasoff, AJ Parsons, SI Ophir, N Lurain… - Journal of …, 2024 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a β-herpesvirus that poses severe disease risk for
immunocompromised patients who experience primary infection or reactivation …
immunocompromised patients who experience primary infection or reactivation …
Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH
AJ Parsons, SI Ophir, JA Duty, TA Kraus… - Communications …, 2022 - nature.com
Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in
immunocompromised individuals including transplant recipients and newborns. New anti …
immunocompromised individuals including transplant recipients and newborns. New anti …