Determining protein–protein functional associations by functional rules based on gene ontology and KEGG pathway

YH Zhang, T Zeng, L Chen, T Huang, YD Cai - Biochimica et Biophysica …, 2021 - Elsevier
Protein–protein interactions (PPIs) describe the direct physical contact of two proteins that
usually results in specific biological functions or regulatory processes. The characterization …

Predicting protein–protein interactions from the molecular to the proteome level

O Keskin, N Tuncbag, A Gursoy - Chemical reviews, 2016 - ACS Publications
Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …

Computational methods for predicting protein‐protein interactions using various protein features

Z Ding, D Kihara - Current protocols in protein science, 2018 - Wiley Online Library
Understanding protein‐protein interactions (PPIs) in a cell is essential for learning protein
functions, pathways, and mechanism of diseases. PPIs are also important targets for …

Protein-protein interaction (PPI) network: recent advances in drug discovery

A Athanasios, V Charalampos… - Current drug …, 2017 - ingentaconnect.com
Background: The investigation of the cellular components, their interactions and related
functions constitute the major conditions in order to understand the cell as an integrated …

Evolution of sequence-based bioinformatics tools for protein-protein interaction prediction

M Khatun, W Shoombuatong, MM Hasan… - Current …, 2020 - ingentaconnect.com
Protein-protein interactions (PPIs) are the physical connections between two or more
proteins via electrostatic forces or hydrophobic effects. Identification of the PPIs is pivotal …

[HTML][HTML] A domain-based approach to predict protein-protein interactions

M Singhal, H Resat - BMC bioinformatics, 2007 - Springer
Background Knowing which proteins exist in a certain organism or cell type and how these
proteins interact with each other are necessary for the understanding of biological processes …

Ensemble learning prediction of protein–protein interactions using proteins functional annotations

I Saha, J Zubek, T Klingström, S Forsberg… - Molecular …, 2014 - pubs.rsc.org
Protein–protein interactions are important for the majority of biological processes. A
significant number of computational methods have been developed to predict protein …

Studying protein–protein interactions: progress, pitfalls and solutions

S Hayes, B Malacrida, M Kiely… - Biochemical Society …, 2016 - portlandpress.com
Signalling proteins are intrinsic to all biological processes and interact with each other in
tightly regulated and orchestrated signalling complexes and pathways. Characterization of …

[HTML][HTML] Benchmark evaluation of protein–protein interaction prediction algorithms

B Dunham, MK Ganapathiraju - Molecules, 2021 - mdpi.com
Protein–protein interactions (PPIs) perform various functions and regulate processes
throughout cells. Knowledge of the full network of PPIs is vital to biomedical research, but …

Discerning molecular interactions: a comprehensive review on biomolecular interaction databases and network analysis tools

SK Miryala, A Anbarasu, S Ramaiah - Gene, 2018 - Elsevier
Computational analysis of biomolecular interaction networks is now gaining a lot of
importance to understand the functions of novel genes/proteins. Gene interaction (GI) …