[HTML][HTML] Micrococcal Nuclease stimulates Staphylococcus aureus Biofilm Formation in a Murine Implant Infection Model

AM Forson, CWK Rosman, TG van Kooten… - Frontiers in Cellular …, 2022 - frontiersin.org
Advancements in contemporary medicine have led to an increasing life expectancy which
has broadened the application of biomaterial implants. As each implant procedure has an …

Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant Staphylococcus aureus USA300

JB Kaplan, AR Horswill - Msphere, 2024 - Am Soc Microbiol
Biofilm formation is an important virulence factor for methicillin-resistant Staphylococcus
aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of …

Interactions between macrophages and biofilm during Staphylococcus aureus-associated implant infection: difficulties and solutions

M Li, J Yu, G Guo, H Shen - Journal of Innate Immunity, 2023 - karger.com
Staphylococcus aureus (S. aureus) biofilm is the major cause of failure of implant infection
treatment that results in heavy social and economic burden on individuals, families, and …

[PDF][PDF] Real-time quantification of matrix metalloproteinase and integrin αvβ3 expression during biomaterial-associated infection in a murine model

S Daghighi, J Sjollema, RJ Dijkstra, V Jaspers… - Eur Cell …, 2014 - research.rug.nl
Biomaterial implants increase the risk of microbial infections due to the biofilm mode of
growth of infecting bacteria on implant materials, in which bacteria are protected against …

Thermonucleases Contribute to Staphylococcus aureus Biofilm Formation in Implant-Associated Infections–A Redundant and Complementary Story

J Yu, F Jiang, F Zhang, M Hamushan, J Du… - Frontiers in …, 2021 - frontiersin.org
Biofilms formed by Staphylococcus aureus are one of the predominant causes of implant-
associated infections (IAIs). Previous studies have found that S. aureus nucleases nuc1 and …

Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus

CWK Rosman, HC van der Mei, J Sjollema - Scientific Reports, 2021 - nature.com
A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus. This
pathogen produces a protective biofilm, making eradication difficult. Biofilms are composed …

Biology and regulation of staphylococcal biofilm

P François, J Schrenzel, F Götz - International Journal of Molecular …, 2023 - mdpi.com
Despite continuing progress in medical and surgical procedures, staphylococci remain the
major Gram-positive bacterial pathogens that cause a wide spectrum of diseases, especially …

Colonization and Infection of Indwelling Medical Devices by Staphylococcus aureus with an Emphasis on Orthopedic Implants

G Pietrocola, D Campoccia, C Motta… - International journal of …, 2022 - mdpi.com
The use of indwelling medical devices has constantly increased in recent years and has
revolutionized the quality of life of patients affected by different diseases. However, despite …

IL-1β Promotes Staphylococcus aureus Biofilms on Implants in vivo

R Gutierrez Jauregui, H Fleige, A Bubke… - Frontiers in …, 2019 - frontiersin.org
Implant associated infections represent a serious health burden in clinics since some
microorganisms are able to colonize biological surfaces or surfaces of indwelling medical …

A Modified Chronic Infection Model for Testing Treatment of Staphylococcus aureus Biofilms on Implants

NP Jørgensen, R Meyer, F Dagnæs-Hansen… - PLoS …, 2014 - journals.plos.org
Bacterial biofilms causing implant-associated osteomyelitis is a severe complication with
limited antimicrobial therapy options. We designed an animal model, in which implant …