Skeletal muscle mitochondrial protein synthesis is regulated in part by insulin. The
development of insulin resistance with diet-induced obesity may therefore contribute to …

Growing evidence supports the theory that mitochondrial dysfunction is an underlying cause
of intramyocellular lipid (IMCL) accumulation and insulin resistance. Here, we hypothesized …

This study sought to elucidate the relationship between skeletal muscle mitochondrial
dysfunction, oxidative stress, and insulin resistance in two mouse models with differential …

New Findings What is the central question of this study? What are the temporal responses of
mitochondrial respiration and mitochondrial responsivity to insulin in soleus muscle fibres …

OBJECTIVE—In obesity and type 2 diabetes, exercise combined with weight loss increases
skeletal muscle mitochondrial capacity. It remains unclear whether mitochondrial capacity …

Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant
offspring of patients with diabetes have≈ 30% less mitochondria in their skeletal muscles …

Background Type 2 diabetes mellitus and muscle insulin resistance have been associated
with reduced capacity of skeletal muscle mitochondria, possibly as a result of increased …

Based on evidence that patients with type 2 diabetes (T2DM), obese insulin-resistant
individuals, and lean insulin-resistant offspring of parents with T2DM have∼ 30% less …

Mitochondria are the combustion engines of life, producing ATP and CO2 at the expense of
nutrient substrates and molecular O2. Given its role in locomotion, skeletal muscle ATP …

Insulin resistance,“a relative impairment in the ability of insulin to exert its effects on glucose,
protein and lipid metabolism in target tissues,” has many detrimental effects on metabolism …