Background The current desirable endpoint of treatment against chronic hepatitis B virus
infection (cHBV) is to achieve a functional cure, which is defined as HBsAg loss (sAg-L) with …

Chronic hepatitis B (CHB) infection functional cure is defined as sustained loss of HBsAg
and several therapeutic strategies are in clinical development designed to …

Background & Aims The immune impairment characterizing chronic hepatitis B (cHBV)
infection is thought to be the consequence of persistent exposure to viral antigens. However …

Objective Hepatitis B virus (HBV)-specific T cells are main effector cells in the control of HBV
infection and hepatitis B surface antigen (HBsAg) is suggested to be a critical factor in the …

Background & Aims Factors associated with a successful outcome upon nucleos (t) ide
analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients …

Background & Aims CD8+ T cells are an essential component of a successful immune
response against hepatitis B virus (HBV). Patients who spontaneously clear HBsAg after …

Background & Aims HBsAg-specific antibody responses are difficult to detect during chronic
hepatitis B infection (CHB) and are often overlooked. The aim of this study was to examine …

Summary In Chronic hepatitis B (CHB) infection, virus and immune response interplay is
thought to be responsible for pathogenesis. Yet, the impact of each immune cell population …

In the era of antiviral therapy, the main goal of treatment has shifted from the persistent
inhibition of hepatitis B virus (HBV) replication to the pursuit of serological clearance of HBs …

BACKGROUND & AIMS: The quantifiable level of HBsAg has been suggested as a predictor
of treatment response in chronic hepatitis B. However, there is limited information on HBsAg …