Background We previously reported that upregulated AMP deaminase (AMPD) contributes
to diastolic ventricular dysfunction via depletion of the adenine nucleotide pool in a rat …

AMP deaminase (AMPD) plays a crucial role in adenine nucleotide metabolism. Recently
we found that upregulated AMPD activity is associated with ATP depletion and contractile …

Diabetes mellitus is one of the major causes of ischemic and nonischemic heart failure.
While hypertension and coronary artery disease are frequent comorbidities in patients with …

Abstract Aims/Introduction We previously showed that upregulation of myocardial adenosine
monophosphate deaminase (AMPD) is associated with pressure overload‐induced diastolic …

Type 2 diabetes mellitus (T2DM) is often complicated with diastolic heart failure, which
decompensates under increased afterload. Focusing on cardiac metabolomes, we …

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol
(ALP), on cardiac dysfunction, oxidative‐nitrosative stress, apoptosis, poly (ADP‐ribose) …

The molecular basis for heart failure is unknown, but oxidative stress is associated with the
pathogenesis of the disease. We tested the hypothesis that the activity of xanthine …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular
remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 …

Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …