Frontotemporal lobar dementia (FTLD) is the most common cause of dementia in patients
younger than 60 years of age, and causes progressive neurodegeneration of the frontal and …

Frontotemporal dementia (FTD) is typified by behavioral and cognitive changes manifested
as altered social comportment and impaired memory performance. To investigate the …

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of
frontotemporal dementia. Most pathogenic GRN mutations result in progranulin …

Progranulin haploinsufficiency causes frontotemporal dementia with tau-negative, ubiquitin-
positive neuronal inclusion pathology. In this study, we showed that progranulin-deficient …

Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …

Progranulin is a highly conserved secreted protein that is expressed in multiple cell types,
both in the CNS and in peripheral tissues. Both directly and via its conversion to granulins …

Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and
is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major …

Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal
dementia (FTD), possibly due to loss of progranulin's neurotrophic and anti-inflammatory …

Deficient progranulin levels cause dose-dependent neurological syndromes:
haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity …