Heterozygous mutations in the granulin (GRN) gene, resulting in the haploinsufficiency of
the progranulin (PGRN) protein, is a leading cause of frontotemporal lobar degeneration …

Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial
frontotemporal lobar degeneration (FTLD). This age-related neurodegenerative disorder …

Loss-of-function mutations in progranulin (GRN) are one of the most common genetic
causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder …

The recent paper by Tanaka and colleagues details the neuropathological consequences of
progranulin knock out in a mouse model. Loss of progranulin function by GRN mutation …

Introduction It has been shown that progranulin (PGRN) deficiency causes age-related
neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and …

Objective The goal of this study was to investigate the effect of progranulin insufficiency on
extracellular vesicles (EVs), a heterogeneous population of vesicles that may contribute to …

Abstract Background and Objective: Reduced progranulin levels are a hallmark of
frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition characterized
by focal degeneration of the frontal and temporal lobes of the brain. Autosomal dominantly …

Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …

Loss‐of‐function mutations in progranulin (GRN) are associated with frontotemporal lobar
degeneration with intraneuronal ubiquitinated protein accumulations composed primarily of …