Progranulin (PGRN) is known to play a role in the pathogenesis of neurodegenerative
diseases. Recently, it has been demonstrated that patients with the homozygous mutation in …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Progranulin is a growth factor involved in the regulation of multiple processes including
tumorigenesis, wound repair, development, and inflammation. The recent discovery that …

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar
degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer's disease …

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar
degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive …

Frontotemporal dementia (FTD) is the second most common dementia before 65 years of
age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Reduction of Tau protein expression was described in 2003 by Zhukareva et al. in a variant
of frontotemporal lobar degeneration (FTLD) referred to as diagnosis of dementia lacking …

Mutations in the granulin (GRN) gene cause frontotemporal dementia (FTD) due to
progranulin haploinsufficiency. Compounds that can increase progranulin production and …

Loss-of-function mutations in the progranulin (GRN) gene are a common cause of
autosomal dominant frontotemporal lobar degeneration, a fatal and progressive …