While reshaping their microenvironment, tumors are also capable of influencing systemic
processes including myeloid cell production. Therefore, the tumor-induced myeloid cells …

Tumor-targeted delivery of anticancer drugs using dendrimers has been recognized as a
promising strategy to increase efficiency and reduce adverse effects of chemotherapy …

Glioblastoma is a rapidly progressing tumor quite resistant to conventional treatment. These
features are currently assigned to a self-sustaining population of glioblastoma stem cells …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with no efficacious treatment.
The application of nanomedicine is expected to bring new hope to PDAC treatment. In this …

In recent years, small nanoparticles (NPs) with a diameter of less than 10 nm have aroused
considerable interest in biomedical applications. However, their intratumor performance, as …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a low
survival rate. The therapeutic effect of chemotherapy and immunotherapy for PDAC is …

Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential
for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we …

Purpose Gemcitabine is the first line and the gold standard drug for pancreatic cancer.
However, the anticancer efficacy is severely limited by its instability and poor cellular uptake …

Polymer mediated drug delivery system represents a novel promising platform for tumor-
targeting with reduced systemic side effects and improved chemotherapeutical efficacy. In …

Currently, the limited penetration of nanoparticles remains a major challenge for antitumor
nanomedicine to penetrate into the tumor tissues. Herein, we propose a size-shrinkable …