Our study aimed to identify differentially methylated regions (ie, genomic region where
multiple adjacent CpG sites show differential methylation) and their enriched genomic …

Our study aimed to identify differentially methylated CpGs/regions and their enriched
genomic pathways associated with underlying chronic musculoskeletal pain in older …

Background The pathoanatomic cause of chronic low back pain (cLBP) cannot be identified
for up to 90% of individuals. However, dysfunctional processing of endogenous nociceptive …

Abstract Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-
Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic …

Nociceptive pain involves the activation of nociceptors without damage to the nervous
system, whereas neuropathic pain is related to an alteration in the central or peripheral …

Objective: Determine if chronic low back pain (LBP) is associated with DNA methylation
signatures in human T cells that will reveal novel mechanisms and potential therapeutic …

Chronic low back pain (cLBP) that cannot be attributable to a specific pathoanatomical
change is associated with high personal and societal costs. Still, the underlying mechanism …

Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component,
which remains to be explained. Epigenetic factors may contribute to and account for some of …

Factors contributing to development of complex regional pain syndrome (CRPS) are not fully
understood. This study examined possible epigenetic mechanisms that may contribute to …

In this study, we sought to characterize synovial tissue obtained from individuals with
arthralgia and disease-specific auto-antibodies and patients with established rheumatoid …