Current treatments for neurodegenerative diseases (ND) are symptomatic and do not affect
disease progression. Slowing this progression remains a crucial unmet need for patients …

Kainic acid (KA) induced seizures provokes an extensive neuronal degeneration initiated by
c-Jun N-terminal kinases (JNK) as central mediators of excitotoxicity. However, the actions of …

As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological
processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at …

JLX001, a novel compound with similar structure with cyclovirobuxine D (CVB-D), has been
proved to exert therapeutical effects on permanent focal cerebral ischemia. However, the …

This study was designed to determine the effects and underlying mechanism of honokiol
(HNK) on traumatic brain injury (TBI). A rat TBI model was constructed using the modified …

JNK3 is a key factor driving the pathophysiology of neuronal apoptosis. Since demonstrating
the therapeutic potential of JNK3 inhibitors in Alzheimer's disease, we aimed to broaden …

Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For
individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the …

Emodin is an active monomer extracted from rhubarb root, which has many biological
functions, including anti‐inflammation, antioxidation, anticancer, and neuroprotection …

c-Jun N-terminal kinases (JNKs) have been recognized as important enzymes in cellular
function. JNK3, which is predominantly found in CNS neurons, has been implicated in …

Abstract Three JNK isoforms, JNK1, JNK2 and JNK3 have been reported and unique
biological function has been ascribed to each. It is unknown if selective inhibition of these …