The potential benefits of gene therapy for neurological diseases such as Parkinson's,
Amyotrophic Lateral Sclerosis (ALS), Epilepsy, and Alzheimer's are enormous. Even a delay …

Publisher Summary The production of biologically active proteins from cloned eukaryotic
genes requires expression of the genes in a eukaryotic cell for the protein to adopt the …

The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) can infect
a variety of mammalian cells, as well as insect cells, facilitating its use as a viral vector for …

This chapter describes methods for growing, purifying, counting, and characterizing viruses.
It also provides general principles of diagnostic virology. As obligate intracellular parasites …

Although viruses are simple biological systems, they are capable of evolving highly efficient
techniques for infecting cells, expressing their genomes, and generating new copies of …

The development of viral vectors for gene therapy has had an interesting and somewhat
tumultuous history but remains the most important avenue tor treatment of a large number of …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

Opportunities for the Use of Lentiviral Vectors in Human Gene Therapy Page 1 Opportunities for
the Use of Lentiviral Vectors in Human Gene Therapy F. GALIMI 1,2 and IM VERMA 1 1 …

Viruses can be engineered to efficiently deliver exogenous genes, but their natural gene
delivery properties often fail to meet human therapeutic needs. Therefore, engineering viral …

Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it
was found that viral vectors were effective carriers of" healthy genes" into patients' cells. The …