Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Objective: The first oxycodone once daily (OOD) has been developed and after successful
pharmacokinetic characterization, therapeutic efficacy and safety were compared to an …

We want to compare the efficacy and side effects of oxycodone and morphine in the
management of postoperative pain by titration in patients who underwent laparoscopic …

Objective: In small to moderate doses, oxycodone has similar analgesic efficacy to morphine
with fewer side effects. The present study evaluated the pharmacokinetics and dynamics of …

ABSTRACT In Japan, Oxycodone hydrochloride injection formulation has been approved in
2012. However, its pharmacokinetics has been poorly studied. The aim of this study is to …

Oxycodone is a semisynthetic opioid analgesic that is increasingly used for the treatment of
acute, cancer, and chronic non-malignant pain. Oxycodone was synthesized in 1917 but its …

Background Standard therapy (ST) for postoperative pain after knee and hip replacement at
the Hamilton Health Sciences Henderson Hospital consists of epidural analgesia or patient …

We have previously shown that paracetamol has an opioid‐sparing effect in tonsillectomy,
and now, we evaluated the analgesic efficacy of paracetamol iv in early post‐operative pain …

Thirty patients with cancer pain completed a double‐blind crossover study comparing
controlled‐release (CR) and immediate‐release (IR) oxycodone. In open‐label titration (2 to …

Chronic pain is a highly disabling condition, which can significantly reduce patients' quality
of life. Prevalence of moderate and severe chronic pain is high in the general population …