Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …

Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …

Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …

Myocardial dysfunction and heart failure perturb cardio-vascular homeostatic signaling
pathways as well as initiate a program of molecular, biochemical, and structural …

Background Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical
source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) …

Background—Accumulating evidence suggests a critical role for increased reactive oxygen
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …

Myocardial oxidative stress and Ca2+ overload induced by ischemia-reperfusion may be
involved in the development and progression of myocardial dysfunction in heart failure …