Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk

T de Sablet, MB Piazuelo, CL Shaffer, BG Schneider… - Gut, 2011 - gut.bmj.com
Background and aims Helicobacter pylori colonises the stomach in half of all humans, and is
the principal cause of gastric cancer, the second leading cause of cancer death worldwide …

Human and Helicobacter pylori coevolution shapes the risk of gastric disease

N Kodaman, A Pazos, BG Schneider… - Proceedings of the …, 2014 - National Acad Sciences
Helicobacter pylori is the principal cause of gastric cancer, the second leading cause of
cancer mortality worldwide. However, H. pylori prevalence generally does not predict cancer …

Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains

Y Yamaoka, M Kato, M Asaka - Internal medicine, 2008 - jstage.jst.go.jp
Certain populations with high incidences of Helicobacter pylori infection, such as those in
East Asian countries, have high incidences of gastric cancer, while other highly infected …

The Relationship Between Helicobacter pylori Infection, the Virulence Genotypes of the Infecting Strain and Gastric Cancer in the African Setting

JA Louw, MSG Kidd, AF Kummer, K Taylor… - …, 2001 - Wiley Online Library
Abstract Background. The relationship between Helicobacter pylori infection and gastric
carcinoma remains controversial, especially in the African setting where infection is …

Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island

SM Devi, I Ahmed, AA Khan, SA Rahman, A Alvi… - BMC genomics, 2006 - Springer
Background Helicobacter pylori is presumed to be co-evolved with its human host and is a
highly diverse gastric pathogen at genetic levels. Ancient origins of H. pylori in the New …

Helicobacter pylori Genotyping and Sequencing Using Paraffin‐Embedded Biopsies from Residents of Colombian Areas with Contrasting Gastric Cancer Risks

LA Sicinschi, P Correa, RM Peek Jr… - …, 2008 - Wiley Online Library
Background: cagA‐positive and vacA s1 and m1 genotypes of Helicobacter pylori are
associated with an elevated risk of gastric cancer (GC). We determined these genotypes …

Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma?

LE Bravo, LJ van Doorn, JL Realpe, P Correa - The American journal of …, 2002 - Elsevier
OBJECTIVES: The aim of this study was to compare the distribution of virulence-associated
genotypes of Helicobacter pylori in two Colombian populations with contrasting gastric …

Helicobacter pylori‐related risk predictors of gastric cancer: The latest models, challenges, and future prospects

SZ Bakhti, S Latifi‐Navid, R Safaralizadeh - Cancer medicine, 2020 - Wiley Online Library
Helicobacter pylori is known as an important determinant of preneoplastic lesions or gastric
cancer (GC) risk. The bacterial genotypes may determine the clinical outcomes. However …

[HTML][HTML] Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway

ZY Munoz-Ramirez, A Mendez-Tenorio… - Frontiers in cellular …, 2017 - frontiersin.org
Helicobacter pylori (HP) genetics may determine its clinical outcomes. Despite high
prevalence of HP infection in Latin America (LA), there have been no phylogenetic studies in …

Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori

R Suzuki, S Shiota, Y Yamaoka - Infection, Genetics and Evolution, 2012 - Elsevier
Helicobacter pylori infection is linked to various gastroduodenal diseases; however, only
approximately 20% of infected individuals develop severe diseases. Despite the high …