Remote ischemic post-conditioning therapy is protective in mouse model of traumatic optic neuropathy

M Nadeem, A Kindelin, L Mahady, K Bhatia… - NeuroMolecular …, 2021 - Springer
Traumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or
direct injury to the optic nerve following blunt head trauma. TON is associated with increased …

Remote ischemic postconditioning promotes the survival of retinal ganglion cells after optic nerve injury

X Liu, O Sha, EYP Cho - Journal of Molecular Neuroscience, 2013 - Springer
Ischemic conditioning, the application of a mild ischemic stimulus to an ischemia-sensitive
structure like the heart or brain either before (preconditioning) or after (postconditioning) its …

Establishment of a minimally invasive distal traumatic optic neuropathy model in mice to investigate cascade reactions of retinal glial cells

B Shen, H Yu, M Zhang, J Chen, Y Zhang… - The FASEB …, 2023 - Wiley Online Library
Traumatic optic neuropathy (TON) is a complication of craniocerebral, orbital and facial
injuries, leading to irreversible vision loss. At present, there is no reliable, widely used …

Protective effects of remote ischemic conditioning against ischemia/reperfusion-induced retinal injury in rats

X Zhang, Y Jizhang, X Xu, TD Kwiecien, N Li… - Visual …, 2014 - cambridge.org
Limb remote ischemic conditioning (LRIC) provides a physiologic strategy for harnessing the
body's endogenous protective capabilities against injury induced by ischemia–reperfusion …

Postconditioning with inhaled carbon monoxide counteracts apoptosis and neuroinflammation in the ischemic rat retina

N Schallner, M Fuchs, CI Schwer, T Loop, H Buerkle… - 2012 - journals.plos.org
Purpose Ischemia and reperfusion injury (I/R) of neuronal structures and organs is
associated with increased morbidity and mortality due to neuronal cell death. We …

Neuroprotective effect of hyperbaric oxygen therapy on anterior ischemic optic neuropathy

BCR Avraham-Lubin, O Dratviman-Storobinsky… - Frontiers in …, 2011 - frontiersin.org
The study investigated the therapeutic effect of hyperbaric oxygen (HBO) on anterior
ischemic optic neuropathy in a rodent model (rAION). rAION was laser-induced in one eye of …

[HTML][HTML] miR-181d-5p Protects against Retinal Ganglion Cell Death after Blunt Ocular Injury by Regulating NFIA-Medicated Astrocyte Development

J Li, J Liu, Y Zhang, X Zha, H Zhang, Y Tang… - Mediators of …, 2022 - hindawi.com
Background. Traumatic optic neuropathy (TON) refers to damage to the optic nerve resulting
from direct and indirect trauma to the head and face. One of the important pathological …

[HTML][HTML] Protective limb remote ischemic post-conditioning against high-intraocular-pressure-induced retinal injury in mice

QJ Zhu, L Zhang, SY Lyu, ZJ Cui… - International Journal of …, 2022 - ncbi.nlm.nih.gov
AIM To determine whether limb remote ischemic post-conditioning (LRIC) protects against
high-intraocular-pressure (IOP)-induced retinal injury, and to identify underlying molecular …

[HTML][HTML] A controlled impact of optic nerve as a new model of traumatic optic neuropathy in mouse

AS Ibrahim, K Elmasry, M Wan… - … & Visual Science, 2018 - jov.arvojournals.org
Purpose: Traumatic optic neuropathy (TON) is the most feared visual consequence of head
and ocular trauma in both military and civilian communities, for which standard treatment …

Preconditioning with carbon monoxide inhalation promotes retinal ganglion cell survival against optic nerve crush via inhibition of the apoptotic pathway

R Wang, Z Chen, J Wu, F Xia… - Molecular …, 2018 - spandidos-publications.com
Optic neurodegeneration, in addition to central nervous trauma, initiates impairments to
neurons resulting in retinal ganglion cell (RGC) damage. Carbon monoxide (CO) has been …