Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells.
Local productions of reactive oxygen species and inflammatory mediators from activated …

Purpose Retinal ischemia and reperfusion injuries (IRI) permanently affect neuronal tissue
and function by apoptosis and inflammation due to the limited regenerative potential of …

Reproducible skills are essential for successful induction of a rat model of anterior ischemic
optic neuropathy (rAION). We established an in vivo validation index by measuring the …

Purpose Retinal ischemia induces apoptosis leading to neurodegeneration and vision
impairment. Carbon monoxide (CO) in gaseous form showed cell-protective and anti …

Traumatic optic neuropathy (TON) can occur following blunt trauma to the orbit and can lead
to permanent vision loss. In this study, we investigated the effectiveness of elamipretide …

Inflammation after acute CNS injury plays a dual role. The interplay between immune cells
and inflammatory mediators is critical to the outcome of injured neurons. Microglia …

Neuroinflammation plays a vital role in the process of a variety of retinal ganglion cells
(RGCs) degenerative diseases including traumatic optic neuropathy (TON). Retinal …

Purpose: Optic nerve (ON) injuries can result in vision loss via structural damage and
cellular injury responses. Understanding the immune response, particularly the role of …

Purpose To investigate the effect of oroxylin A on the survival of retinal ganglion cells (RGC)
and the activation of microglial cells in a rat optic nerve (ON) crush model. Methods Oroxylin …

Objective: To create an animal (rat) model of force percussion injury (FPI) to the optic nerve
for clinical and experimental research. Methods: Seventy-one healthy female Wister rats …