Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern …

AM Egloff, JW Lee, CJ Langer, H Quon, A Vaezi… - Clinical Cancer …, 2014 - AACR
Purpose: Treatment with cisplatin or cetuximab combined with radiotherapy each yield
superior survival in locally advanced squamous cell head and neck cancer (LA-SCCHN) …

Cetuximab and radiotherapy versus cisplatin and radiotherapy for locally advanced head and neck cancer: a randomized phase II trial

SM Magrini, M Buglione, R Corvò, L Pirtoli… - Journal of Clinical …, 2016 - ascopubs.org
Purpose No randomized trials have been conducted to directly compare radiotherapy (RT)
with concomitant cisplatin (CDDP) versus concomitant cetuximab (CTX) as first-line …

Concurrent cetuximab, cisplatin, and radiotherapy (RT) for loco-regionally advanced squamous cell carcinoma of the head and neck (SCCHN): updated results of a …

YB Su, DH Kraus, MJ Zelefsky, E Lis… - Journal of Clinical …, 2005 - ascopubs.org
5529 Background: We previously reported results of a phase 2 study of concurrent
cetuximab, a chimeric monoclonal antibody directed against the epidermal growth factor …

Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with …

JA Bonner, PM Harari, J Giralt, N Azarnia… - Journal of Clinical …, 2004 - ascopubs.org
5507 Background: The majority of head and neck cancers overexpress the epidermal
growth factor receptor (EGFR), which is associated with aggressive tumor behavior and poor …

A phase 2 open label, single-arm trial to evaluate the combination of cetuximab plus taxotere, cisplatin, and 5-flurouracil as an induction regimen in patients with …

R Mesía, S Vázquez, JJ Grau, JA García-Sáenz… - International Journal of …, 2016 - Elsevier
Purpose Despite treatment, prognosis of unresectable squamous cell carcinoma of the head
and neck (SCCHC) is dismal. Cetuximab therapy has proven to increase the clinical activity …

Cisplatin versus cetuximab given concurrently with definitive radiation therapy for locally advanced head and neck squamous cell carcinoma

J Ley, P Mehan, TM Wildes, W Thorstad, HA Gay… - Oncology, 2013 - karger.com
Objective: Whether or not cisplatin and cetuximab are similarly effective in improving
outcomes when added to radiation therapy (RT) in squamous cell carcinoma of the head …

Cetuximab and radiation therapy versus cisplatin and radiation therapy for locally advanced head and neck cancer: Long-term survival and toxicity outcomes of a …

M Maddalo, P Borghetti, D Tomasini, R Corvò… - International Journal of …, 2020 - Elsevier
Purpose This study describes the long-term survival and toxicity outcomes of a multicenter
randomized phase 2 trial comparing radiation therapy (RT) plus cisplatin (CDDP) or …

Cetuximab/radiotherapy (CET+ RT) versus concomitant chemoradiotherapy (cCHT+ RT) with or without induction docetaxel/cisplatin/5-fluorouracil (TPF) in locally …

MG Ghi, A Paccagnella, D Ferrari, P Foa, F Nole… - 2012 - ascopubs.org
5513 Background: The standard treatment options for LASCCHN are cCHT+ RT or CET+
RT. Strategies to improve the efficacy with the integration of induction chemotherapy are …

Cetuximab therapy for head and neck squamous cell carcinoma: a systematic review of the data

TD Reeves, EG Hill, KE Armeson… - … --Head and Neck …, 2011 - journals.sagepub.com
Objective. To review the current state of the data on the use of cetuximab in head and neck
squamous cell carcinoma (HNSCC). Data Sources. The National Center for Biotechnology …

Cetuximab in the treatment of head and neck cancer: preliminary results outside clinical trials

D Dequanter, M Shahla, P Paulus… - Cancer management …, 2010 - Taylor & Francis
Introduction The purpose of this study was to evaluate the clinical efficacy in our daily
practice, outside clinical trials, of cetuximab plus radiotherapy in a majority of treatment …