[HTML][HTML] FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells
SHE Park, A Kulkarni, G Konopka - PLoS biology, 2023 - journals.plos.org
During cortical development, human basal radial glial cells (bRGCs) are highly capable of
sustained self-renewal and neurogenesis. Selective pressures on this cell type may have …
sustained self-renewal and neurogenesis. Selective pressures on this cell type may have …
[PDF][PDF] Foxp1 regulates neural stem cell self-renewal and bias toward deep layer cortical fates
CA Pearson, DM Moore, HO Tucker, JD Dekker, H Hu… - Cell reports, 2020 - cell.com
The laminar architecture of the mammalian neocortex depends on the orderly generation of
distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we …
distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we …
[HTML][HTML] Transcription and beyond: delineating FOXG1 function in cortical development and disorders
Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant
roles in brain development, where alteration of this gene's expression significantly affects …
roles in brain development, where alteration of this gene's expression significantly affects …
Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis
Neocortical astrogenesis follows neuronogenesis and precedes oligogenesis. Among key
factors dictating its temporal articulation, there are progression rates of pallial stem cells …
factors dictating its temporal articulation, there are progression rates of pallial stem cells …
Foxp2 regulates neuronal differentiation and neuronal subtype specification
YC Chiu, MY Li, YH Liu, JY Ding, JY Yu… - Developmental …, 2014 - Wiley Online Library
Mutations of the transcription factor FOXP2 in humans cause a severe speech and language
disorder. Disruption of Foxp2 in songbirds or mice also leads to deficits in song learning or …
disorder. Disruption of Foxp2 in songbirds or mice also leads to deficits in song learning or …
FoxP2 regulates neurogenesis during embryonic cortical development
D Tsui, JP Vessey, H Tomita, DR Kaplan… - Journal of …, 2013 - Soc Neuroscience
The transcription factor FoxP2 has been associated with the development of human speech
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
[HTML][HTML] FoxG1 directly represses dentate granule cell fate during forebrain development
X Han, X Gu, Q Zhang, Q Wang, Y Cheng… - Frontiers in Cellular …, 2018 - frontiersin.org
The cortex consists of 100s of neuronal subtypes that are organized into distinct functional
regions; however, the mechanisms underlying cell fate determination remain unclear. Foxg1 …
regions; however, the mechanisms underlying cell fate determination remain unclear. Foxg1 …
[HTML][HTML] Foxp1 Regulates Cortical Radial Migration and Neuronal Morphogenesis in Developing Cerebral Cortex
X Li, J Xiao, H Fröhlich, X Tu, L Li, Y Xu, H Cao, J Qu… - PloS one, 2015 - journals.plos.org
FOXP1 is a member of FOXP subfamily transcription factors. Mutations in FOXP1 gene have
been found in various development-related cognitive disorders. However, little is known …
been found in various development-related cognitive disorders. However, little is known …
[HTML][HTML] Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing
aspects of cognitive function in humans, non-human mammals, and song-learning birds …
aspects of cognitive function in humans, non-human mammals, and song-learning birds …
[PDF][PDF] FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells
NC Hettige, H Peng, H Wu, X Zhang, V Yerko, Y Zhang… - Stem Cell Reports, 2022 - cell.com
Heterozygous loss-of-function mutations in Forkhead box G1 (FOXG1), a uniquely brain-
expressed gene, cause microcephaly, seizures, and severe intellectual disability, whereas …
expressed gene, cause microcephaly, seizures, and severe intellectual disability, whereas …