MicroRNAs (miRNAs) are rapidly emerging as a new layer of regulation of mammalian brain
development. However, most of the miRNA target genes remain unidentified. Here, we …

The critical stem cell transcription factor FoxD3 is expressed by the premigratory and
migrating neural crest, an embryonic stem cell population that forms diverse derivatives …

Abstract Background The transcription factor Foxg1 is an important regulator of
telencephalic cell cycles. Its inactivation causes premature lengthening of telencephalic …

What are the factors that are induced during the transitory phases from pluripotent stem cells
to lineage specified cells, how are they regulated, and what are their functional contributions …

Brain development is a highly regulated process that involves the precise spatio-temporal
activation of cell signaling cues. Transcription factors play an integral role in this process by …

Vertebrate development culminates in the generation of proper proportions of a large variety
of different cell types and subtypes essential for tissue, organ and system functions in the …

New cells are continuously generated from immature proliferating cells in the adult brain in
two neurogenic niches known as the subgranular zone (SGZ) of the dentate gyrus (DG) of …

FOXG1 (forkhead box G1) syndrome is a neurodevelopmental disorder caused by variants
in the Foxg1 gene that affect brain structure and function. Individuals affected by FOXG1 …

The neural crest (NC) is a transient embryonic stem cell-like population characterized by its
multipotency and broad developmental potential. Here, we perform NC-specific …

The role of transcription factors in regulating the development of midbrain dopaminergic
(mDA) neurons is intensively studied owing to the involvement of these neurons in diverse …